Patricia McCracken January 30, 2019 Constipation, Manual Physical Therapy Effect of Connective Tissue Manipulation on Symptoms and Quality of Life in Patients With Chronic Constipation: a Randomized Controlled Trial Patricia McCracken January 30, 2019 Constipation, Manual Physical Therapy This study showed that connective tissue massage and lifestyle advice were superior to reducing symptoms of constipation and quality of life compared with lifestyle advice alone for patients with chronic constipation.